Causes

Neurofibromatosis is caused by genetic mutations that lead to the abnormal growth of nerve tissue. In most cases, these mutations are inherited from a parent who also has the condition. However, it is possible for the genetic mutations to occur spontaneously in individuals with no family history of the disorder. 

The specific genes involved in neurofibromatosis are known as NF1 and NF2. Mutations in the NF1 gene are responsible for the development of neurofibromatosis type 1, while mutations in the NF2 gene lead to neurofibromatosis type 2. Research is ongoing to better understand the genetic factors that contribute to neurofibromatosis and to develop more effective treatment strategies.