Causes of Pheochromocytoma

The exact cause of pheochromocytoma is not fully understood, but it is believed to be related to genetic mutations that occur in the cells of the adrenal gland. These mutations can cause the cells to grow and divide uncontrollably, leading to the formation of a tumor. In some cases, pheochromocytoma may be associated with certain genetic syndromes, such as multiple endocrine neoplasia type 2 (MEN2) and von Hippel-Lindau disease. 

These syndromes can increase the risk of developing tumors in the adrenal glands and other endocrine organs. While most cases of pheochromocytoma are not hereditary, individuals with a family history of the condition may have an increased risk of developing it themselves.